Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.
Nat Rev Genet
; 19(3): 160-174, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-29279606
ABSTRACT
Nuclear receptors (NRs) have historically been at the forefront of cancer research, where they are known to act as critical regulators of disease. They also serve as biomarkers for tumour subclassification and targets for hormone therapy. However, most tumour types express extensive repertoires of NRs, whose interactions provide multiple paths for disease progression and offer potentially untapped mechanisms for therapeutic interventions. Recently, next-generation sequencing technologies have provided genome-wide insights into the complex interplay of NR transcriptional networks and their contribution to the development and progression of cancer. These findings have altered the traditional understanding of NR activities in oncogenesis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transcripción Genética
/
Transducción de Señal
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Receptores Citoplasmáticos y Nucleares
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Redes Reguladoras de Genes
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Proteínas de Neoplasias
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Revista:
Nat Rev Genet
Asunto de la revista:
GENETICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos