Herpes Simplex Virus 1 Mutant with Point Mutations in <i>UL39</i> Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation.

Mostafa, Heba H; Thompson, Thornton W; Konen, Adam J; Haenchen, Steve D; Hilliard, Joshua G; Macdonald, Stuart J; Morrison, Lynda A; Davido, David J

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation.

Mostafa, Heba H; Thompson, Thornton W; Konen, Adam J; Haenchen, Steve D; Hilliard, Joshua G; Macdonald, Stuart J; Morrison, Lynda A; Davido, David J.

Afiliación

Mostafa HH; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Thompson TW; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Konen AJ; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Haenchen SD; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Hilliard JG; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Macdonald SJ; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Morrison LA; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Davido DJ; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA ddavido@ku.edu.

J Virol ; 92(7)2018 04 01.

Article en En | MEDLINE | ID: mdl-29321311

Asunto(s)

Proteínas de la Cápside; Herpes Simple; Herpesvirus Humano 1/fisiología; Mutación Puntual; Activación Viral/genética; Latencia del Virus/genética; Animales; Proteínas de la Cápside/genética; Proteínas de la Cápside/metabolismo; Chlorocebus aethiops; Modelos Animales de Enfermedad; Femenino; Herpes Simple/genética; Herpes Simple/metabolismo; Herpes Simple/patología; Vacunas contra el Virus del Herpes Simple/genética; Vacunas contra el Virus del Herpes Simple/metabolismo; Ratones; Células Vero; Proteínas Virales/biosíntesis; Proteínas Virales/genética

Palabras clave

HSV-1; ICP6; UL39; antiapoptosis; pathogenesis; ribonucleotide reductase; viral mutant

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activación Viral / Mutación Puntual / Latencia del Virus / Herpesvirus Humano 1 / Proteínas de la Cápside / Herpes Simple Límite: Animals Idioma: En Revista: J Virol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google