Immune Responses in the Liver.
Annu Rev Immunol
; 36: 247-277, 2018 04 26.
Article
en En
| MEDLINE
| ID: mdl-29328785
ABSTRACT
The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering the body via the gut, the liver appears designed to detect, capture, and clear bacteria, viruses, and macromolecules. Containing the largest collection of phagocytic cells in the body, this organ is an important barrier between us and the outside world. Importantly, as portal blood also transports a large number of foreign but harmless molecules (e.g., food antigens), the liver's default immune status is anti-inflammatory or immunotolerant; however, under appropriate conditions, the liver is able to mount a rapid and robust immune response. This balance between immunity and tolerance is essential to liver function. Excessive inflammation in the absence of infection leads to sterile liver injury, tissue damage, and remodeling; insufficient immunity allows for chronic infection and cancer. Dynamic interactions between the numerous populations of immune cells in the liver are key to maintaining this balance and overall tissue health.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fenómenos del Sistema Inmunológico
/
Hígado
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Immunol
Año:
2018
Tipo del documento:
Article