A high-risk 70-gene signature is not associated with the detection of tumor cell dissemination to the bone marrow.
Breast Cancer Res Treat
; 169(2): 305-309, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29374853
ABSTRACT
PURPOSE:
The 70-gene signature (70-GS) is a prognostic tool, grouping patients in risk groups to assess their need for adjuvant chemotherapy. Tumor cell dissemination to the bone marrow is a marker of minimal residual disease and associated with impaired survival. In this study, we aimed to evaluate whether 70-GS is associated with the presence of disseminated tumor cells (DTCs) in the bone marrow of patients with early breast cancer.METHODS:
In patients with hormone receptor-positive HER2-negative early breast cancer, the 70-GS was obtained and the presence of DTCs was immunohistochemically evaluated using cytokeratin staining with the A45-B/B3 antibody.RESULTS:
149 patients were included into the analysis. 40 (27%) had a high-risk 70-GS and 35 (23%) had detectable DTCs in their bone marrow. 9 (22%) of the 40 patients with high-risk 70-GS and 26 (24%) of the 109 patients with a low-risk 70-GS were positive for DTCs (p = 0.863).CONCLUSIONS:
As both 70-GS and DTC detection are known prognostic factors but do not seem to correlate, a follow-up on a larger cohort is warranted to evaluate if a combination of the two is able to better stratify the relapse risk in early breast cancer patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pronóstico
/
Neoplasias de la Mama
/
Neoplasia Residual
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Breast Cancer Res Treat
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania