RNA Biology in Retinal Development and Disease.
Trends Genet
; 34(5): 341-351, 2018 05.
Article
en En
| MEDLINE
| ID: mdl-29395379
ABSTRACT
For decades, RNA has served in a supporting role between the genetic carrier (DNA) and the functional molecules (proteins). It is finally time for RNA to take center stage in all aspects of biology. The retina provides a unique opportunity to dissect the molecular underpinnings of neuronal diversity and disease. Transcriptome profiles of the retina and its resident cell types have unraveled unique features of the RNA landscape. The discovery of distinct RNA molecules and the recognition that RNA processing is a major cause of retinal neurodegeneration have prompted the design of biomarkers and novel therapeutic paradigms. We review here RNA biology as it pertains to the retina, emphasizing new avenues for investigations in development and disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Retina
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Enfermedades de la Retina
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Regulación de la Expresión Génica
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ARN no Traducido
Límite:
Animals
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Humans
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos