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Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.
Yamauchi, Takuji; Masuda, Takeshi; Canver, Matthew C; Seiler, Michael; Semba, Yuichiro; Shboul, Mohammad; Al-Raqad, Mohammed; Maeda, Manami; Schoonenberg, Vivien A C; Cole, Mitchel A; Macias-Trevino, Claudio; Ishikawa, Yuichi; Yao, Qiuming; Nakano, Michitaka; Arai, Fumio; Orkin, Stuart H; Reversade, Bruno; Buonamici, Silvia; Pinello, Luca; Akashi, Koichi; Bauer, Daniel E; Maeda, Takahiro.
Afiliación
  • Yamauchi T; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan; Department of Stem Cell Biology and Medicine, K
  • Masuda T; Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
  • Canver MC; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Seiler M; H3 Biomedicine, Inc., Cambridge, MA 02139, USA.
  • Semba Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan.
  • Shboul M; Institute of Medical Biology, A∗STAR, 8A Biomedical Grove, Singapore 138648, Singapore.
  • Al-Raqad M; Institute of Medical Biology, A∗STAR, 8A Biomedical Grove, Singapore 138648, Singapore; Al-Balqa Applied University, Faculty of Science, Al-Salt, Salt 19117, Jordan.
  • Maeda M; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Schoonenberg VAC; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Cole MA; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Macias-Trevino C; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Ishikawa Y; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Yao Q; Department of Pathology & Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Nakano M; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan.
  • Arai F; Department of Stem Cell Biology and Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan.
  • Orkin SH; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Reversade B; Institute of Medical Biology, A∗STAR, 8A Biomedical Grove, Singapore 138648, Singapore.
  • Buonamici S; H3 Biomedicine, Inc., Cambridge, MA 02139, USA.
  • Pinello L; Department of Pathology & Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan.
  • Bauer DE; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Maeda T; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan. Electronic address: t_maeda@cancer.med.kyushu-u.ac.jp.
Cancer Cell ; 33(3): 386-400.e5, 2018 03 12.
Article en En | MEDLINE | ID: mdl-29478914
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Atrofia Muscular Espinal / Leucemia / Endorribonucleasas / Sistemas CRISPR-Cas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Atrofia Muscular Espinal / Leucemia / Endorribonucleasas / Sistemas CRISPR-Cas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article