Attenuated behaviour in Cornelia de Lange and fragile X syndromes.
J Intellect Disabil Res
; 62(6): 486-495, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29536582
BACKGROUND: Catatonia-like presentations in people with autism have been increasingly recognised within research and diagnostic guidelines. The recently developed Attenuated Behaviour Questionnaire has identified that attenuated behaviour [autistic catatonia] is very prevalent in people with autism spectrum disorders (ASDs) and associated with repetitive behaviour. In the current study, we investigated attenuated behaviour within two genetic syndromes associated with ASD and examined ASD and repetitive behaviour as longitudinal predictors of attenuated behaviour. METHOD: The Attenuated Behaviour Questionnaire was completed by parents/carers of 33 individuals with Cornelia de Lange syndrome (CdLS) and 69 with fragile X syndrome (FXS). Information collected from the same informants 4 years previously was utilised to examine ASD and repetitive behaviour as predictors of later attenuated behaviour, controlling for age, gender and ability. RESULTS: Catatonia-like attenuated behaviour was reported for individuals with CdLS (30.3%) and FXS (11.6%). Slowed movement was more prevalent in people with CdLS. No other phenotypic differences were observed. Across the two groups, repetitive behaviour predicted the presence of attenuated behaviour 4 years later, after controlling for age, gender and ability. CONCLUSIONS: Attenuated behaviour can be identified in individuals with CdLS and FXS and may have an effect on both adaptive behaviour and quality of life. Repetitive behaviours predicted subsequent risk within both groups and should be assessed by services as part of a pro-active strategy of support.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Catatonia
/
Trastorno de Movimiento Estereotipado
/
Síndrome de Cornelia de Lange
/
Trastorno del Espectro Autista
/
Síndrome del Cromosoma X Frágil
Tipo de estudio:
Guideline
/
Prognostic_studies
/
Qualitative_research
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Intellect Disabil Res
Asunto de la revista:
TRANSTORNOS MENTAIS
Año:
2018
Tipo del documento:
Article