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Identified OAS3 gene variants associated with coexistence of HBsAg and anti-HBs in chronic HBV infection.
Wang, S; Wang, J; Fan, M-J; Li, T-Y; Pan, H; Wang, X; Liu, H-K; Lin, Q-F; Zhang, J-G; Guan, L-P; Zhernakova, D V; O'Brien, S J; Feng, Z-R; Chang, L; Dai, E-H; Lu, J-H; Xi, H-L; Zeng, Z; Yu, Y-Y; Wang, B-B.
Afiliación
  • Wang S; Department of Infectious Diseases, Peking University First Hospital, Beijing, China.
  • Wang J; Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
  • Fan MJ; Center for Genetics, National Research Institute for Family Planning, Beijing, China.
  • Li TY; Department of Infectious Diseases, Peking University First Hospital, Beijing, China.
  • Pan H; Center for Genetics, National Research Institute for Family Planning, Beijing, China.
  • Wang X; Center for Genetics, National Research Institute for Family Planning, Beijing, China.
  • Liu HK; Center for Genetics, National Research Institute for Family Planning, Beijing, China.
  • Lin QF; BGI-Shenzhen, Shenzhen, China.
  • Zhang JG; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Guan LP; BGI-Shenzhen, Shenzhen, China.
  • Zhernakova DV; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • O'Brien SJ; BGI-Shenzhen, Shenzhen, China.
  • Feng ZR; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Chang L; BGI-Shenzhen, Shenzhen, China.
  • Dai EH; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Lu JH; Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg, Russia.
  • Xi HL; Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg, Russia.
  • Zeng Z; Department of Laboratory Medicines, Peking University First Hospital, Beijing, China.
  • Yu YY; Department of Laboratory Medicines, Peking University First Hospital, Beijing, China.
  • Wang BB; The Fifth Hospital of Shijiazhuang, Shijiazhuang, China.
J Viral Hepat ; 25(8): 904-910, 2018 08.
Article en En | MEDLINE | ID: mdl-29582521
The underlying mechanism of coexistence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antigen antibody (anti-HBs) is still controversial. To identify the host genetic factors related to this unusual clinical phenomenon, a two-stage study was conducted in the Chinese Han population. In the first stage, we performed a case-control (1:1) age- and gender-matched study of 101 cases with concurrent HBsAg and anti-HBs and 102 controls with negative HBsAg and positive anti-HBs using whole exome sequencing. In the second validation stage, we directly sequence the 16 exons on the OAS3 gene in two dependent cohorts of 48 cases and 200 controls. Although, in the first stage, a genome-wide association study of 58,563 polymorphism variants in 101 cases and 102 controls found no significant loci (P-value ≤ .05/58563), and neither locus achieved a conservative genome-wide significance threshold (P-value ≤ 5e-08), gene-based burden analysis showed that OAS3 gene rare variants were associated with the coexistence of HBsAg and anti-HBs. (P-value = 4.127e-06 ≤ 0.05/6994). A total of 16 rare variants were screened out from 21 cases and 3 controls. In the second validation stage, one case with a stop-gained rare variant was identified. Fisher's exact test of all 149 cases and 302 controls showed that the rare coding sequence mutations were more frequent in cases vs controls (P-value = 7.299e-09, OR = 17.27, 95% CI [5.01-58.72]). Protein-coding rare variations on the OAS3 gene are associated with the coexistence of HBsAg and anti-HBs in patients with chronic HBV infection in Chinese Han population.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Variación Genética / 2',5'-Oligoadenilato Sintetasa / Hepatitis B Crónica / Anticuerpos contra la Hepatitis B / Antígenos de Superficie de la Hepatitis B Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Viral Hepat Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Variación Genética / 2',5'-Oligoadenilato Sintetasa / Hepatitis B Crónica / Anticuerpos contra la Hepatitis B / Antígenos de Superficie de la Hepatitis B Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Viral Hepat Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China