FGF2 Enhances Odontoblast Differentiation by αSMA+ Progenitors In Vivo.
J Dent Res
; 97(10): 1170-1177, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29649366
ABSTRACT
The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo. We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis. Our results demonstrate that early delivery of exogenous FGF2 to exposed pulp led to proliferative expansion of αSMA-tdTomato+ cells and their accelerated differentiation into odontoblasts. In vivo lineage-tracing experiments showed that the calcified bridge/reparative dentin in FGF2-treated pulps were lined with an increased number of Dspp+ odontoblasts and devoid of BSP+ osteoblasts. The increased number of odontoblasts derived from αSMA-tdTomato+ cells and the formation of reparative dentin devoid of osteoblasts provide in vivo evidence for the stimulatory effects of FGF signaling on odontoblast differentiation from early progenitors in dental pulp.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factor 2 de Crecimiento de Fibroblastos
/
Odontoblastos
Límite:
Animals
Idioma:
En
Revista:
J Dent Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos