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Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis.
Albers, Lucia; Sobotzki, Christina; Kuß, Oliver; Ajslev, Teresa; Batista, Rosangela Fl; Bettiol, Heloisa; Brabin, Bernard; Buka, Stephen L; Cardoso, Viviane C; Clifton, Vicki L; Devereux, Graham; Gilman, Stephen E; Grzeskowiak, Luke E; Heinrich, Joachim; Hummel, Sandra; Jacobsen, Geir W; Jones, Graeme; Koshy, Gibby; Morgen, Camilla Schmidt; Oken, Emily; Paus, Tomas; Pausova, Zdenka; Rifas-Shiman, Sheryl L; Sharma, Andrea J; da Silva, Antônio Am; Sørensen, Thorkild Ia; Thiering, Elisabeth; Turner, Stephen; Vik, Torstein; von Kries, Rüdiger.
Afiliación
  • Albers L; Division of Epidemiology, Institute of Social Paediatrics and Adolescents Medicine, Ludwig-Maximilians-University Munich, Munich, Germany. lucia.albers@med.uni-muenchen.de.
  • Sobotzki C; Division of Epidemiology, Institute of Social Paediatrics and Adolescents Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Kuß O; German Diabetes Center, Institute of Biometrics and Epidemiology, Düsseldorf, 40225, Germany.
  • Ajslev T; Department of Clinical Epidemiology (formerly Institute of Preventive Medicine), Bispebjerg and Frederiksberg Hospitals, The Capital Region, Denmark.
  • Batista RF; Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís, MA, Brazil.
  • Bettiol H; Departamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
  • Brabin B; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Buka SL; Department of Community Child Health,Royal Liverpool Children's Hospital, NHS Trust Alder Hey, Liverpool, UK.
  • Cardoso VC; Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
  • Clifton VL; Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.
  • Devereux G; Departamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
  • Gilman SE; Adelaide Medical School, The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
  • Grzeskowiak LE; Child Health, University of Aberdeen, Aberdeen, UK.
  • Heinrich J; Health Behavior Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
  • Hummel S; Department of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, Boston, MA, USA.
  • Jacobsen GW; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
  • Jones G; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Koshy G; Adelaide Medical School, The Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
  • Morgen CS; Institute of Occupational, Social, and Environmental Medicine, University Hospital, Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Occupational, Social, and Environmental Medicine, University Hospital, Neuherberg, Germany.
  • Oken E; Forschergruppe Diabetes der Technischen Universität München, Munich, Germany.
  • Paus T; Institut für Diabetesforschung der Forschergruppe Diabetes e.V. am Helmholtz Zentrum München, Munich, Germany.
  • Pausova Z; Department of Public Health and General Practice, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Rifas-Shiman SL; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
  • Sharma AJ; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK.
  • da Silva AA; Department of Clinical Epidemiology (formerly Institute of Preventive Medicine), Bispebjerg and Frederiksberg Hospitals, The Capital Region, Denmark.
  • Sørensen TI; Obesity Prevention Program, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Thiering E; Rotman Research Institute and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada.
  • Turner S; Hospital for Sick Children and Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada.
  • Vik T; Obesity Prevention Program, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • von Kries R; Centers for Disease Control and Prevention, Atlanta, USA.
Int J Obes (Lond) ; 42(7): 1249-1264, 2018 07.
Article en En | MEDLINE | ID: mdl-29717267
BACKGROUND/OBJECTIVES: A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear. SUBJECT/METHODS: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex. RESULTS: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results. CONCLUSIONS: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Fumar / Desarrollo Infantil / Mujeres Embarazadas / Obesidad Infantil Tipo de estudio: Etiology_studies / Systematic_reviews Límite: Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn / Pregnancy Idioma: En Revista: Int J Obes (Lond) Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Fumar / Desarrollo Infantil / Mujeres Embarazadas / Obesidad Infantil Tipo de estudio: Etiology_studies / Systematic_reviews Límite: Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn / Pregnancy Idioma: En Revista: Int J Obes (Lond) Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Alemania