ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aß production independently of their cholesterol efflux capacity.

Dafnis, Ioannis; Raftopoulou, Christina; Mountaki, Christina; Megalou, Evgenia; Zannis, Vassilis I; Chroni, Angeliki

Dafnis, Ioannis; Raftopoulou, Christina; Mountaki, Christina; Megalou, Evgenia; Zannis, Vassilis I; Chroni, Angeliki.

Afiliación

Dafnis I; Institute of Biosciences and Applications, National Center for Scientific Research 'Demokritos', Agia Paraskevi, Athens 15341, Greece.
Raftopoulou C; Institute of Biosciences and Applications, National Center for Scientific Research 'Demokritos', Agia Paraskevi, Athens 15341, Greece.
Mountaki C; Institute of Biosciences and Applications, National Center for Scientific Research 'Demokritos', Agia Paraskevi, Athens 15341, Greece.
Megalou E; Institute of Biosciences and Applications, National Center for Scientific Research 'Demokritos', Agia Paraskevi, Athens 15341, Greece.
Zannis VI; Departments of Medicine and Biochemistry, Molecular Genetics, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, U.S.A.
Chroni A; Institute of Biosciences and Applications, National Center for Scientific Research 'Demokritos', Agia Paraskevi, Athens 15341, Greece achroni@bio.demokritos.gr.

Biochem J ; 475(10): 1839-1859, 2018 05 31.

Article en En | MEDLINE | ID: mdl-29743204

Asunto(s)

Secretasas de la Proteína Precursora del Amiloide/metabolismo; Péptidos beta-Amiloides/metabolismo; Apolipoproteína E4/metabolismo; Ácido Aspártico Endopeptidasas/metabolismo; Colesterol/metabolismo; Neuroblastoma/metabolismo; Neuronas/metabolismo; Animales; Apolipoproteína E4/genética; Transporte Biológico; Células Cultivadas; Humanos; Masculino; Ratones; Ratones Endogámicos C57BL; Neuroblastoma/patología; Neuronas/citología; Isoformas de Proteínas; Eliminación de Secuencia

Palabras clave

Alzheimer's disease; amyloid-ß; apolipoproteins; cholesterol

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Colesterol / Péptidos beta-Amiloides / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide / Apolipoproteína E4 / Neuroblastoma / Neuronas Tipo de estudio: Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Biochem J Año: 2018 Tipo del documento: Article País de afiliación: Grecia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google