Genetic polymorphism in RANK is associated with mandibular size.
J Orthod
; 45(3): 157-162, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29798716
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans.DESIGN:
DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM-A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism.SETTING:
School of Dentistry of Ribeirão Preto, University of São Paulo.PARTICIPANTS:
A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study.RESULTS:
The polymorphism in RANK was associated with a higher Go-Pg measurement (p = .039). In the multivariate analysis, adjusted for age and gender, the polymorphism in RANK was associated with Go-Pg (p = .017) and Co-Gn (p = .043).CONCLUSION:
The polymorphism rs3826620 in RANK is associated with the mandibular size.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo de Nucleótido Simple
/
Osteoprotegerina
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Orthod
Asunto de la revista:
ODONTOLOGIA
/
ORTODONTIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Brasil