Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration.
Neurocase
; 24(2): 111-120, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29799310
ABSTRACT
Primary progressive apraxia of speech (PPAOS) is a neurodegenerative disorder in which AOS is the sole presenting complaint. We report clinical and neuroimaging data spanning 10 years from disease onset-to-death in a 49 year-old male PPAOS patient, DY, who died with corticobasal degeneration. He presented with AOS with normal neuroimaging. Abnormalities in the caudate nucleus, supplementary motor area, cingulate, insula, and Broca's area were observed after five years, with involvement of motor cortex and development of agrammatism, Parkinsonism, and dysarthria three years later. Cognitive impairment and temporoparietal atrophy were late features. This data provides important insight into disease progression of corticobasal degeneration when presenting as PPAOS.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apraxias
/
Trastornos del Habla
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Ganglios Basales
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Corteza Cerebral
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Enfermedades Neurodegenerativas
Límite:
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurocase
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos