Genomescale analysis to identify potential prognostic microRNA biomarkers for predicting overall survival in patients with colon adenocarcinoma.
Oncol Rep
; 40(4): 1947-1958, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30066920
ABSTRACT
The aim of the present study was to identify potential prognostic microRNA (miRNA) biomarkers for colon adenocarcinoma (COAD) prognostic prediction using the dataset of The Cancer Genome Atlas (TCGA). The genomewide miRNA sequencing dataset and corresponding COAD clinical information were downloaded from TCGA. Prognosisrelated miRNA screening was performed by genomewide multivariable Cox regression analysis and used for prognostic signature construction. Ten miRNAs (hsamir891a, hsamir6854, hsamir216a, hsamir378d1, hsamir92a1, hsamir4709, hsamir92a2, hsamir210, hsamir940 and hsamir887) were identified as prognostic miRNAs and used for further prognostic signature construction. The 10miRNA prognostic signature showed good performance in prognosis prediction (adjusted P<0.0001; adjusted hazard ratio, 4.580; 95% confidence interval, 2.7837.538). In the timedependent receiver operating characteristic analysis, the area under the curve was 0.735, 0.788, 0.806, 0.806, 0.775 and 0.900 for 1, 2, 3, 4, 5 and 10year COAD overall survival prediction, respectively. Comprehensive survival analysis suggested that the 10miRNA prognostic signature is an independent prognostic factor in COAD, with a better performance in COAD overall survival prediction than other traditional clinical parameters. Functional enrichment indicated that the corresponding target genes were significantly enriched in multiple biological processes and pathways, including regulation of cell proliferation, cell cycle, cell growth, and Wnt and transforming growth factorß signaling pathways. In conclusion, our present study identified a 10miRNA expression signature that may serve as a potential prognostic biomarker in COAD patients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
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Biomarcadores de Tumor
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Regulación Neoplásica de la Expresión Génica
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Genoma Humano
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Neoplasias del Colon
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MicroARNs
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Oncol Rep
Asunto de la revista:
NEOPLASIAS
Año:
2018
Tipo del documento:
Article