Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes.

Fang, Yuanying; Xu, Jun; Li, Zhifeng; Yang, Zunhua; Xiong, Lijuan; Jin, Yi; Wang, Qi; Xie, Saisai; Zhu, Wufu; Chang, Sheng

Fang, Yuanying; Xu, Jun; Li, Zhifeng; Yang, Zunhua; Xiong, Lijuan; Jin, Yi; Wang, Qi; Xie, Saisai; Zhu, Wufu; Chang, Sheng.

Afiliación

Fang Y; National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Xu J; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Li Z; National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Yang Z; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address: joshyyy@126.com.
Xiong L; National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Jin Y; National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Wang Q; National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Xie S; National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Zhu W; College of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China.
Chang S; College of Pharmacy, Jilin Medical University, Jilin 132013, China. Electronic address: changsheng-pharm@hotmail.com.

Bioorg Med Chem ; 26(14): 4080-4087, 2018 08 07.

Article en En | MEDLINE | ID: mdl-30100020

Asunto(s)

Antihipertensivos/farmacología; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Diseño de Fármacos; Pirimidinas/farmacología; Receptores Acoplados a Proteínas G/agonistas; Animales; Antihipertensivos/síntesis química; Antihipertensivos/química; Células CHO; Cricetulus; Diabetes Mellitus Experimental/tratamiento farmacológico; Relación Dosis-Respuesta a Droga; Prueba de Tolerancia a la Glucosa; Ratones; Ratones Endogámicos C57BL; Estructura Molecular; Pirimidinas/síntesis química; Pirimidinas/química; Relación Estructura-Actividad

Palabras clave

GPR119 agonist; Pyrimido[5,4-d]pyrimidine; Type 2 diabetes; oGTT

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / Diseño de Fármacos / Receptores Acoplados a Proteínas G / Diabetes Mellitus Tipo 2 / Antihipertensivos Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China

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