Increased Binding of Specificity Protein 1 to the <i>IL21R</i> Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis.

Dam, Elizabeth M; Maier, Alison C; Hocking, Anne M; Carlin, Jeffrey; Ng, Bernard; Buckner, Jane H

Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis.

Dam, Elizabeth M; Maier, Alison C; Hocking, Anne M; Carlin, Jeffrey; Ng, Bernard; Buckner, Jane H.

Afiliación

Dam EM; Translational Research Program, Benaroya Research Institute, Seattle, WA, United States.
Maier AC; Translational Research Program, Benaroya Research Institute, Seattle, WA, United States.
Hocking AM; Translational Research Program, Benaroya Research Institute, Seattle, WA, United States.
Carlin J; Division of Rheumatology, Virginia Mason Medical Center, Seattle, WA, United States.
Ng B; Rheumatology Section, VA Puget Sound Health Care System, Seattle, WA, United States
Buckner JH; Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, United States

Front Immunol ; 9: 1978, 2018.

Article en En | MEDLINE | ID: mdl-30233580

Asunto(s)

Artritis Reumatoide/inmunología; Linfocitos B/inmunología; Regiones Promotoras Genéticas/genética; Receptores de Interleucina-21/genética; Factor de Transcripción Sp1/metabolismo; Adulto; Animales; Células Cultivadas; Estudios de Cohortes; Estudios Transversales; Humanos; Memoria Inmunológica; Interleucinas/metabolismo; Activación de Linfocitos; Ratones; Persona de Mediana Edad; Unión Proteica; Transducción de Señal

Palabras clave

B cells; IL-21R; IL-6; rheumatoid arthritis; specificity protein 1

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Artritis Reumatoide / Linfocitos B / Factor de Transcripción Sp1 / Regiones Promotoras Genéticas / Receptores de Interleucina-21 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Humans / Middle aged Idioma: En Revista: Front Immunol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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