Involvement of complement 3 in the salt-sensitive hypertension by activation of renal renin-angiotensin system in spontaneously hypertensive rats.

Negishi, Eriko; Fukuda, Noboru; Otsuki, Tomoyasu; Katakawa, Mayumi; Komatsu, Kazutoshi; Chen, Lan; Tanaka, Sho; Kobayashi, Hiroki; Hatanaka, Yoshinari; Ueno, Takahiro; Endo, Morito; Mashimo, Tomoji; Nishiyama, Akira; Abe, Masanori

Negishi, Eriko; Fukuda, Noboru; Otsuki, Tomoyasu; Katakawa, Mayumi; Komatsu, Kazutoshi; Chen, Lan; Tanaka, Sho; Kobayashi, Hiroki; Hatanaka, Yoshinari; Ueno, Takahiro; Endo, Morito; Mashimo, Tomoji; Nishiyama, Akira; Abe, Masanori.

Afiliación

Negishi E; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Fukuda N; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Otsuki T; Research Center, Nihon University , Tokyo , Japan.
Katakawa M; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Komatsu K; Division of Cell Regeneration and Transplantation, Department of Functional Morphology, Nihon University School of Medicine , Tokyo , Japan.
Chen L; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Tanaka S; Division of Cell Regeneration and Transplantation, Department of Functional Morphology, Nihon University School of Medicine , Tokyo , Japan.
Kobayashi H; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Hatanaka Y; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Ueno T; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Endo M; Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine , Tokyo , Japan.
Mashimo T; Faculty of Human Health Science, Hachinohe Gakuin University, Hachinohe, Aomori, Japan.
Nishiyama A; Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University , Osaka , Japan.
Abe M; Department of Pharmacology, Kagawa University School of Medicine , Takamatsu, Kagawa , Japan.

Am J Physiol Renal Physiol ; 315(6): F1747-F1758, 2018 12 01.

Article en En | MEDLINE | ID: mdl-30256128

Asunto(s)

Presión Sanguínea; Complemento C3/metabolismo; Hipertensión/metabolismo; Riñón/metabolismo; Sistema Renina-Angiotensina; Cloruro de Sodio Dietético; Angiotensinógeno/genética; Angiotensinógeno/metabolismo; Animales; Presión Sanguínea/genética; Cadherinas/genética; Cadherinas/metabolismo; Desdiferenciación Celular; Proliferación Celular; Células Cultivadas; Complemento C3/genética; Modelos Animales de Enfermedad; Predisposición Genética a la Enfermedad; Hipertensión/genética; Hipertensión/patología; Hipertensión/fisiopatología; Riñón/patología; Riñón/fisiopatología; Factores de Transcripción de Tipo Kruppel/genética; Factores de Transcripción de Tipo Kruppel/metabolismo; Receptores X del Hígado/genética; Receptores X del Hígado/metabolismo; Masculino; Fenotipo; Ratas Endogámicas SHR; Ratas Endogámicas WKY; Ratas Transgénicas; Renina/genética; Renina/metabolismo; Sistema Renina-Angiotensina/genética; Transducción de Señal

Palabras clave

complement 3; fibrosis; gene editing; renin-angiotensin system; spontaneously hypertensive rat

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Presión Sanguínea / Complemento C3 / Cloruro de Sodio Dietético / Hipertensión / Riñón Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Am J Physiol Renal Physiol Asunto de la revista: FISIOLOGIA / NEFROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Japón

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