A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation.

Monteiro, Maria B; Ramm, Susanne; Chandrasekaran, Vidya; Boswell, Sarah A; Weber, Elijah J; Lidberg, Kevin A; Kelly, Edward J; Vaidya, Vishal S

Monteiro, Maria B; Ramm, Susanne; Chandrasekaran, Vidya; Boswell, Sarah A; Weber, Elijah J; Lidberg, Kevin A; Kelly, Edward J; Vaidya, Vishal S.

Afiliación

Monteiro MB; Harvard Program in Therapeutic Science, Harvard Medical School Laboratory of Systems Pharmacology, Boston, Massachusetts.
Ramm S; Harvard Program in Therapeutic Science, Harvard Medical School Laboratory of Systems Pharmacology, Boston, Massachusetts.
Chandrasekaran V; Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Boswell SA; Harvard Program in Therapeutic Science, Harvard Medical School Laboratory of Systems Pharmacology, Boston, Massachusetts.
Weber EJ; Harvard Program in Therapeutic Science, Harvard Medical School Laboratory of Systems Pharmacology, Boston, Massachusetts.
Lidberg KA; Department of Pharmaceutics, University of Washington, Seattle, Washington; and.
Kelly EJ; Department of Pharmaceutics, University of Washington, Seattle, Washington; and.
Vaidya VS; Department of Pharmaceutics, University of Washington, Seattle, Washington; and.

J Am Soc Nephrol ; 29(12): 2820-2833, 2018 12.

Article en En | MEDLINE | ID: mdl-30361326

Asunto(s)

Túbulos Renales/efectos de los fármacos; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores; Proteínas Tirosina Quinasas/antagonistas & inhibidores; Lesión Renal Aguda/tratamiento farmacológico; Técnicas de Cultivo de Célula/métodos; Ciclo Celular/efectos de los fármacos; Ciclo Celular/genética; Proliferación Celular/efectos de los fármacos; Proliferación Celular/genética; Células Cultivadas; Descubrimiento de Drogas; Evaluación Preclínica de Medicamentos; Células Epiteliales/citología; Células Epiteliales/efectos de los fármacos; Células Epiteliales/enzimología; Ensayos Analíticos de Alto Rendimiento; Humanos; Túbulos Renales/citología; Túbulos Renales/enzimología; Proteínas Serina-Treonina Quinasas/metabolismo; Proteínas Tirosina Quinasas/metabolismo; Medicina Regenerativa; Quinasas DyrK

Palabras clave

Acute kidney injury; DYRK inhibitor; ID-8; Regenerative medicine; proliferation; renal tubular epithelial cells

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Proteínas Serina-Treonina Quinasas / Inhibidores de Proteínas Quinasas / Túbulos Renales Límite: Humans Idioma: En Revista: J Am Soc Nephrol Asunto de la revista: NEFROLOGIA Año: 2018 Tipo del documento: Article

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