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Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.
Reilly, Sean W; Puentes, Laura N; Schmitz, Alexander; Hsieh, Chia-Ju; Weng, Chi-Chang; Hou, Catherine; Li, Shihong; Kuo, Yin-Ming; Padakanti, Prashanth; Lee, Hsiaoju; Riad, Aladdin A; Makvandi, Mehran; Mach, Robert H.
Afiliación
  • Reilly SW; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Puentes LN; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
  • Schmitz A; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hsieh CJ; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Weng CC; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hou C; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Li S; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kuo YM; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Padakanti P; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Lee H; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Riad AA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Makvandi M; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: makvandi@pennmedicine.upenn.edu.
  • Mach RH; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: rmach@mail.med.upenn.edu.
Bioorg Chem ; 83: 242-249, 2019 03.
Article en En | MEDLINE | ID: mdl-30390553
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ftalazinas / Piperidinas / Barrera Hematoencefálica / Poli(ADP-Ribosa) Polimerasa-1 Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ftalazinas / Piperidinas / Barrera Hematoencefálica / Poli(ADP-Ribosa) Polimerasa-1 Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos