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Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort.
Thompson, George R; Krois, Charles R; Affolter, Verena K; Everett, Angela D; Varjonen, E Katarina; Sharon, Victoria R; Singapuri, Anil; Dennis, Michael; McHardy, Ian; Yoo, Hong Sik; Fedor, Dawn M; Wiederhold, Nathan P; Aaron, Phylicia A; Gelli, Angie; Napoli, Joseph L; White, Stephen D.
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  • Thompson GR; Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA grthompson@ucdavis.edu.
  • Krois CR; Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, Davis, California, USA.
  • Affolter VK; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
  • Everett AD; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
  • Varjonen EK; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
  • Sharon VR; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
  • Singapuri A; Department of Dermatology, Zucker School of Medicine at Hofstra Northwell, Hempstead, New York, USA.
  • Dennis M; Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA.
  • McHardy I; Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA.
  • Yoo HS; Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA.
  • Fedor DM; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
  • Wiederhold NP; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
  • Aaron PA; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA.
  • Gelli A; Department of Pharmacology, University of California, Davis, Davis, California, USA.
  • Napoli JL; Department of Pharmacology, University of California, Davis, Davis, California, USA.
  • White SD; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Antimicrob Agents Chemother ; 63(2)2019 02.
Article en En | MEDLINE | ID: mdl-30455235
Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fluconazol / Alopecia Areata / Antifúngicos Límite: Animals / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fluconazol / Alopecia Areata / Antifúngicos Límite: Animals / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos