Mitochondria as central regulators of neural stem cell fate and cognitive function.
Nat Rev Neurosci
; 20(1): 34-48, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30464208
ABSTRACT
Emerging evidence now indicates that mitochondria are central regulators of neural stem cell (NSC) fate decisions and are crucial for both neurodevelopment and adult neurogenesis, which in turn contribute to cognitive processes in the mature brain. Inherited mutations and accumulated damage to mitochondria over the course of ageing serve as key factors underlying cognitive defects in neurodevelopmental disorders and neurodegenerative diseases, respectively. In this Review, we explore the recent findings that implicate mitochondria as crucial regulators of NSC function and cognition. In this respect, mitochondria may serve as targets for stem-cell-based therapies and interventions for cognitive defects.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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Diferenciación Celular
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Cognición
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Células-Madre Neurales
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Mitocondrias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Canadá