Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-Î³ and NF-&#954;B.

Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto-Alarcon, Sandra; Ortiz, Macarena; Videla, Luis A

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-Î³ and NF-κB.

Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto-Alarcon, Sandra; Ortiz, Macarena; Videla, Luis A.

Afiliación

Illesca P; Biochemistry Department, Faculty of Biochemistry, University of Litoral, Santa Fe, Argentina.
Valenzuela R; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile. Electronic address: rvalenzuelab@med.uchile.cl.
Espinosa A; Medical Technology Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Echeverría F; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Soto-Alarcon S; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Ortiz M; Nutriton and Dietetics School, Faculty of Health Sciences, Catholic University of Maule, Curicó, Chile.
Videla LA; Molecular and Clinical Pharmacology Program, Institute of Biomedical Science, Faculty of Medicine, University of Chile, Santiago, Chile.

Biomed Pharmacother ; 109: 2472-2481, 2019 Jan.

Article en En | MEDLINE | ID: mdl-30551508

Asunto(s)

Tejido Adiposo Blanco/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; FN-kappa B/metabolismo; PPAR gamma/metabolismo; Alcohol Feniletílico/análogos & derivados; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo; Tejido Adiposo Blanco/efectos de los fármacos; Animales; Antioxidantes/farmacología; Antioxidantes/uso terapéutico; Dieta Alta en Grasa/efectos adversos; Dieta Alta en Grasa/tendencias; Masculino; Enfermedades Metabólicas/tratamiento farmacológico; Enfermedades Metabólicas/etiología; Enfermedades Metabólicas/metabolismo; Ratones; Ratones Endogámicos C57BL; FN-kappa B/antagonistas & inhibidores; Alcohol Feniletílico/farmacología; Alcohol Feniletílico/uso terapéutico; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/antagonistas & inhibidores; Factores de Transcripción/metabolismo

Palabras clave

Hydroxytyrosol; NF-κB; Nrf2; Oxidative stress; PPAR-Î³; White adipose tissue

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Alcohol Feniletílico / FN-kappa B / PPAR gamma / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Factor 2 Relacionado con NF-E2 / Tejido Adiposo Blanco Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2019 Tipo del documento: Article País de afiliación: Argentina

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