Structure-based switch of regioselectivity in the flavin-dependent tryptophan 6-halogenase Thal.

Moritzer, Ann-Christin; Minges, Hannah; Prior, Tina; Frese, Marcel; Sewald, Norbert; Niemann, Hartmut H

Moritzer, Ann-Christin; Minges, Hannah; Prior, Tina; Frese, Marcel; Sewald, Norbert; Niemann, Hartmut H.

Afiliación

Moritzer AC; From the Structural Biochemistry and.
Minges H; Organic and Bioorganic Chemistry Research Groups, Department of Chemistry, Bielefeld University, Universitätsstrasse 25, D-33615 Bielefeld, Germany.
Prior T; From the Structural Biochemistry and.
Frese M; Organic and Bioorganic Chemistry Research Groups, Department of Chemistry, Bielefeld University, Universitätsstrasse 25, D-33615 Bielefeld, Germany.
Sewald N; Organic and Bioorganic Chemistry Research Groups, Department of Chemistry, Bielefeld University, Universitätsstrasse 25, D-33615 Bielefeld, Germany.
Niemann HH; From the Structural Biochemistry and hartmut.niemann@uni-bielefeld.de.

J Biol Chem ; 294(7): 2529-2542, 2019 02 15.

Article en En | MEDLINE | ID: mdl-30559288

Asunto(s)

Proteínas Bacterianas/química; Oxidorreductasas/química; Streptomyces/enzimología; Proteínas Bacterianas/genética; Dominio Catalítico; Cristalografía por Rayos X; Oxidorreductasas/genética; Streptomyces/genética; Relación Estructura-Actividad; Especificidad por Sustrato

Palabras clave

FAD-dependent halogenase; biocatalysis; crystal structure; enzyme catalysis; enzyme design; enzyme engineering; enzyme structure; flavoprotein; protein design; protein engineering; tryptophan

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Streptomyces / Proteínas Bacterianas Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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