Integrated molecular characterization of adult soft tissue sarcoma for therapeutic targets.
BMC Med Genet
; 19(Suppl 1): 216, 2018 12 31.
Article
en En
| MEDLINE
| ID: mdl-30598078
ABSTRACT
BACKGROUND:
Several studies have investigated the molecular drivers and therapeutic targets in adult soft tissue sarcomas. However, such studies are limited by the genomic heterogeneity and rarity of sarcomas, particularly in those with complex and unbalanced karyotypes. Additional biomarkers are needed across sarcoma types to improve therapeutic strategies. To investigate the molecular characteristics of complex karyotype sarcomas (CKSs) for therapeutic targets, we performed genomic profiling.RESULTS:
The mutational landscape showed that TP53, ATRX, and PTEN genes were highly mutated. CKS samples were categorized into three groups based on copy number variations that were associated with CDK4 and RB1 signatures. Integrated analysis of genomic and transcriptomic data revealed several pathways related to PDGFR, which could be a strategic target for anti-sarcoma therapy.CONCLUSIONS:
This study provides a detailed molecular classification of CKSs and proposes several therapeutic targets. Targeted or combinational therapies for treating CKS should be considered before chemotherapy.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Neoplasias de los Tejidos Blandos
/
Regulación Neoplásica de la Expresión Génica
/
Receptor alfa de Factor de Crecimiento Derivado de Plaquetas
/
Ubiquitina-Proteína Ligasas
/
Quinasa 4 Dependiente de la Ciclina
/
Proteínas de Unión a Retinoblastoma
/
Proteínas de Neoplasias
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
BMC Med Genet
Asunto de la revista:
GENETICA MEDICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Corea del Sur