Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template.

Gall, Flavio M; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R E; Sievers, Martin; Riedl, Rainer

Gall, Flavio M; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R E; Sievers, Martin; Riedl, Rainer.

Afiliación

Gall FM; Institute of Chemistry and Biotechnology, Center of Organic and Medicinal Chemistry, ZHAW Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
Hohl D; Institute of Chemistry and Biotechnology, Center of Organic and Medicinal Chemistry, ZHAW Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
Frasson D; Institute of Chemistry and Biotechnology, Center of Molecular Biology, ZHAW Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
Wermelinger T; Institute of Chemistry and Biotechnology, Center of Molecular Biology, ZHAW Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
Mittl PRE; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Sievers M; Institute of Chemistry and Biotechnology, Center of Molecular Biology, ZHAW Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
Riedl R; Institute of Chemistry and Biotechnology, Center of Organic and Medicinal Chemistry, ZHAW Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.

Angew Chem Int Ed Engl ; 58(12): 4051-4055, 2019 03 18.

Article en En | MEDLINE | ID: mdl-30615822

Asunto(s)

Diseño de Fármacos; Inhibidores de Proteasas/química; Sitios de Unión; Cristalografía por Rayos X; Ciclización; Metaloproteinasa 13 de la Matriz/química; Metaloproteinasa 13 de la Matriz/metabolismo; Inhibidores de la Metaloproteinasa de la Matriz/síntesis química; Inhibidores de la Metaloproteinasa de la Matriz/química; Inhibidores de la Metaloproteinasa de la Matriz/metabolismo; Simulación de Dinámica Molecular; Péptidos Cíclicos/química; Péptidos Cíclicos/metabolismo; Peptidomiméticos; Inhibidores de Proteasas/síntesis química; Inhibidores de Proteasas/metabolismo; Inhibidores Tisulares de Metaloproteinasas/química

Palabras clave

drug design; medicinal chemistry; peptidomimetics; structural biology; structure-activity relationship

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Diseño de Fármacos Tipo de estudio: Diagnostic_studies Idioma: En Revista: Angew Chem Int Ed Engl Año: 2019 Tipo del documento: Article País de afiliación: Suiza

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