<i>ERG</i> deletions in childhood acute lymphoblastic leukemia with <i>DUX4</i> rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity.

Zaliova, Marketa; Potuckova, Eliska; Hovorkova, Lenka; Musilova, Alena; Winkowska, Lucie; Fiser, Karel; Stuchly, Jan; Mejstrikova, Ester; Starkova, Julia; Zuna, Jan; Stary, Jan; Trka, Jan

ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity.

Zaliova, Marketa; Potuckova, Eliska; Hovorkova, Lenka; Musilova, Alena; Winkowska, Lucie; Fiser, Karel; Stuchly, Jan; Mejstrikova, Ester; Starkova, Julia; Zuna, Jan; Stary, Jan; Trka, Jan.

Afiliación

Zaliova M; CLIP - Childhood Leukaemia Investigation Prague marketa.zaliova@lfmotol.cuni.cz.
Potuckova E; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague.
Hovorkova L; University Hospital Motol, Prague, Czech Republic.
Musilova A; CLIP - Childhood Leukaemia Investigation Prague.
Winkowska L; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague.
Fiser K; CLIP - Childhood Leukaemia Investigation Prague.
Stuchly J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague.
Mejstrikova E; CLIP - Childhood Leukaemia Investigation Prague.
Starkova J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague.
Zuna J; CLIP - Childhood Leukaemia Investigation Prague.
Stary J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague.
Trka J; CLIP - Childhood Leukaemia Investigation Prague.

Haematologica ; 104(7): 1407-1416, 2019 07.

Article en En | MEDLINE | ID: mdl-30630977

Asunto(s)

Biomarcadores de Tumor/genética; Eliminación de Gen; Reordenamiento Génico; Proteínas de Homeodominio/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras B/diagnóstico; Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética; Adolescente; Niño; Preescolar; Femenino; Estudios de Seguimiento; Regulación Neoplásica de la Expresión Génica; Humanos; Lactante; Masculino; Leucemia-Linfoma Linfoblástico de Células Precursoras B/clasificación; Pronóstico; Estudios Retrospectivos; Tasa de Supervivencia; Regulador Transcripcional ERG/genética

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Reordenamiento Génico / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Biomarcadores de Tumor / Eliminación de Gen / Proteínas de Homeodominio Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Haematologica Año: 2019 Tipo del documento: Article

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