Synthesis of Fused Indolines by Interrupted Fischer Indolization in a Microfluidic Reactor.
Tetrahedron Lett
; 60(3): 322-326, 2019 Jan 17.
Article
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| MEDLINE
| ID: mdl-30631216
ABSTRACT
This study describes our development of a microfluidic reaction scheme for the synthesis of fused indoline ring systems found in several bioactive compounds. We have utilized a continuous-flow microfluidic reactor for the reaction of hydrazines with latent aldehydes through the interrupted Fischer indolization reaction to form fused indoline and azaindoline products. We have identified optimal conditions and evaluated the scope of this microfluidic reaction using various hydrazine and latent aldehyde surrogates. This green chemistry approach can be of general utility to rapidly produce indoline scaffolds and intermediates in a continuous manner.
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos