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Sex differences in the progressive model of parkinsonism induced by reserpine in rats.
Bispo, José M M; Melo, João E C; Gois, Auderlan M; Leal, Pollyana C; Lins, Lívia C R F; Souza, Marina F; Medeiros, Katty A A L; Ribeiro, Alessandra M; Silva, Regina H; Marchioro, Murilo; Santos, José R.
Afiliación
  • Bispo JMM; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Melo JEC; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Gois AM; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Leal PC; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Lins LCRF; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Souza MF; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Medeiros KAAL; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Ribeiro AM; Department of Biosciences, Federal University of São Paulo, Santos, SP, Brazil.
  • Silva RH; Department of Pharmacology, Federal University of São Paulo, São Paulo, SP, Brazil.
  • Marchioro M; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
  • Santos JR; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil. Electronic address: joseronaldosantos@gmail.com.
Behav Brain Res ; 363: 23-29, 2019 05 02.
Article en En | MEDLINE | ID: mdl-30690108
ABSTRACT
Parkinson's disease (PD) exhibits sexual differences in susceptibility and pathogenesis in humans, with a high incidence in men and a high severity of motor symptoms in male rodents. Furthermore, studies showed that the administration of low dose of reserpine (RES) induces a progressive appearance of motor alterations similar with parkinsonism in male rodents. Here, we investigated sex differences in motor deficits and tyrosine hydroxylase (TH) immunoreactivity induced by a progressive model of parkinsonism. Gonadally intact male and female Wistar rats and ovariectomized female rats received 15 subcutaneous injections (s.c.) every other day of 0.1 mg/kg of RES or vehicle. The repeated administration of low doses of RES (0.1 mg/kg) produces sexually dimorphic impairments on motor performance (catalepsy and open field test). Intact and ovariectomized females were more resistant to the deleterious effect of repeated administration of reserpine in the early, but this resistance in intact female disappears over time. However, intact females showed a reduction of the TH immunoreactivity in substantia nigra pars compacta, but not in ventral tegmental area and dorsal striatum. These results suggest a possible application of this model in the study of sexual dimorphism throughout the progression of PD.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores Sexuales / Trastornos Parkinsonianos / Actividad Motora Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2019 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores Sexuales / Trastornos Parkinsonianos / Actividad Motora Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2019 Tipo del documento: Article País de afiliación: Brasil