Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease.
J Exp Med
; 216(3): 482-500, 2019 03 04.
Article
en En
| MEDLINE
| ID: mdl-30755454
ABSTRACT
Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell types, these IFN-induced GTPases assemble into large nanomachines that execute distinct host defense activities against a wide variety of microbial pathogens. In addition, GBPs customize inflammasome responses to bacterial infection and sepsis, where they act as critical rheostats to amplify innate immunity and regulate tissue damage. Similar functions are becoming evident for metabolic inflammatory syndromes and cancer, further underscoring the importance of GBPs within infectious as well as altered homeostatic settings. A better understanding of the basic biology of these IFN-induced GTPases could thus benefit clinical approaches to a wide spectrum of important human diseases.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Interferones
/
Proteínas de Unión al GTP
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Interacciones Huésped-Patógeno
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Interacciones Huésped-Parásitos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Exp Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Moldova