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Development and validation of the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI): a novel instrument to quantify organ damage in systemic sclerosis.
Ferdowsi, Nava; Huq, Molla; Stevens, Wendy; Hudson, Marie; Wang, Mianbo; Tay, Tien; Burchell, Jodie L; Mancuso, Sam; Rabusa, Candice; Sundararajan, Vijaya; Prior, David; Proudman, Susanna M; Baron, Murray; Nikpour, Mandana.
Afiliación
  • Ferdowsi N; Department of Medicine, University of Melbourne at St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Huq M; Rheumatology, St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Stevens W; Department of Medicine, University of Melbourne at St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Hudson M; Rheumatology, St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Wang M; Rheumatology, St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Tay T; Medicine, University of McGill, Montreal, Quebec, Canada.
  • Burchell JL; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.
  • Mancuso S; Department of Medicine, University of Melbourne at St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Rabusa C; Rheumatology, St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Sundararajan V; Department of Medicine, University of Melbourne at St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Prior D; Department of Medicine, University of Melbourne at St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Proudman SM; Rheumatology, St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
  • Baron M; Public Health, LaTrobe University, Melbourne, Victoria, Australia.
  • Nikpour M; Department of Medicine, University of Melbourne at St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia.
Ann Rheum Dis ; 78(6): 807-816, 2019 06.
Article en En | MEDLINE | ID: mdl-30928903
ABSTRACT

OBJECTIVE:

We sought to develop the first Damage Index (DI) in systemic sclerosis (SSc).

METHODS:

The conceptual definition of 'damage' in SSc was determined through consensus by a working group of the Scleroderma Clinical Trials Consortium (SCTC). Systematic literature review and consultation with patient partners and non-rheumatologist experts produced a list of potential items for inclusion in the DI. These steps were used to reduce the items (1) Expert members of the SCTC (n=331) were invited to rate the appropriateness of each item for inclusion, using a web-based survey. Items with >60% consensus were retained; (2) Using a prospectively acquired Australian cohort data set of 1568 patients, the univariable relationships between the remaining items and the endpoints of mortality and morbidity (Physical Component Summary score of the Short Form 36) were analysed, and items with p<0.10 were retained; (3) using multivariable regression analysis, coefficients were used to determine a weighted score for each item. The DI was externally validated in a Canadian cohort.

RESULTS:

Ninety-three (28.1%) complete survey responses were analysed; 58 of 83 items were retained. The univariable relationships with death and/or morbidity endpoints were statistically significant for 22 items, with one additional item forced into the multivariable model by experts due to clinical importance, to create a 23-item weighted SCTC DI (SCTC-DI). The SCTC-DI was predictive of morbidity and mortality in the external cohort.

CONCLUSIONS:

Through the combined use of consensus and data-driven methods, a 23-item SCTC-DI was developed and retrospectively validated.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Índice de Severidad de la Enfermedad Tipo de estudio: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: Ann Rheum Dis Año: 2019 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Índice de Severidad de la Enfermedad Tipo de estudio: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: Ann Rheum Dis Año: 2019 Tipo del documento: Article País de afiliación: Australia