Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade.
Nat Biomed Eng
; 3(8): 598-610, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-30962587
ABSTRACT
Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for additional removal surgery. Here, we describe a thermogelling polymer that provides an internal tamponade effect through surface tension and swelling counter-forces. We tested the long-term biocompatibility of the polymer endotamponade in rabbit vitrectomy models, and its surgical efficacy and biocompatibility in a non-human primate retinal-detachment model. We also show that, while the thermogel biodegrades during the three months following surgery, it promotes the reformation of a vitreous-like body that mimics the biophysical properties of the natural vitreous. The thermogelling endotamponade might serve as a long-term vitreous substitute.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polímeros
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Cuerpo Vítreo
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Desprendimiento de Retina
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Endotaponamiento
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Nat Biomed Eng
Año:
2019
Tipo del documento:
Article
País de afiliación:
Singapur