Biomechanical Impact of Localized Corneal Cross-linking Beyond the Irradiated Treatment Area.
J Refract Surg
; 35(4): 253-260, 2019 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-30984983
ABSTRACT
PURPOSE:
To investigate the stiffening effect of localized corneal cross-linking (L-CXL) within and beyond the irradiated region in three dimensions.METHODS:
Ten porcine eyes were debrided of epithelium and incrementally soaked with 0.1% riboflavin solution. Using a customized, sharp-edged mask, half of the cornea was blocked while the other half was exposed to blue light (447 nm). The three-dimensional biomechanical properties of each cornea were then measured via Brillouin microscopy. An imaging system was used to quantify the optimal transition zone between cross-linked and non-cross-linked sections of the cornea when considering light propagation and scattering.RESULTS:
A broad transition zone of 610 µm in width was observed between the fully cross-linked and non-cross-linked sections, indicating the stiffening response extended beyond the irradiated region. Light propagation and the scattering induced by the riboflavin-soaked cornea accounted for a maximum of 25 and 159 ± 3.2 µm, respectively.CONCLUSIONS:
The stiffening effect of L-CXL extends beyond that of the irradiated area. When considering L-CXL protocols clinically, it will be important to account for increased stiffening in surrounding regions. [J Refract Surg. 2019;35(4)253-260.].
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fármacos Fotosensibilizantes
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Córnea
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Reactivos de Enlaces Cruzados
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Elasticidad
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
J Refract Surg
Asunto de la revista:
OFTALMOLOGIA
Año:
2019
Tipo del documento:
Article