Abnormal expression of the co-stimulatory molecule B7-H3 in lichen simplex chronicus is associated with expansion of Langerhans cells.
Clin Exp Dermatol
; 45(1): 30-35, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31056761
ABSTRACT
BACKGROUND:
The co-stimulatory molecule B7-H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC).AIM:
To investigate if abnormal expression of the co-stimulatory molecule B7-H3 in LSC is associated with Langerhans cell (LC) expansion.METHODS:
We used immunohistochemistry to stain LSC skin tissue, and evaluated if the immunostaining of B7-H3 and interleukin (IL)-6 was significantly different.RESULTS:
Our results indicated that B7-H3 is abnormally expressed in LSC skin tissue and positively regulates LC expansion. We also found that IL-6 might modulate B7-H3 expression. Moreover, LC expansion in LSC leads to the proliferation of T cells.CONCLUSIONS:
Our study indicates the potential value of immunotherapy as a treatment for LSC.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piel
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Células de Langerhans
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Interleucina-6
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Antígenos B7
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Neurodermatitis
Tipo de estudio:
Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Exp Dermatol
Año:
2020
Tipo del documento:
Article
País de afiliación:
China