Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration.

Sano, Tomohiko; Akeda, Koji; Yamada, Junichi; Takegami, Norihiko; Sudo, Takao; Sudo, Akihiro

Sano, Tomohiko; Akeda, Koji; Yamada, Junichi; Takegami, Norihiko; Sudo, Takao; Sudo, Akihiro.

Afiliación

Sano T; Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.
Akeda K; Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan. k_akeda@clin.medic.mie-u.ac.jp.
Yamada J; Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.
Takegami N; Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.
Sudo T; Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.
Sudo A; Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.

BMC Musculoskelet Disord ; 20(1): 225, 2019 May 17.

Article en En | MEDLINE | ID: mdl-31101043

Asunto(s)

Degeneración del Disco Intervertebral/patología; Disco Intervertebral/patología; Osteoprotegerina/metabolismo; Ligando RANK/metabolismo; Receptor Activador del Factor Nuclear kappa-B/metabolismo; Anciano; Anciano de 80 o más Años; Animales; Células Cultivadas; Condrocitos; Progresión de la Enfermedad; Femenino; Fibroblastos; Humanos; Disco Intervertebral/citología; Degeneración del Disco Intervertebral/cirugía; Masculino; Ratones; Persona de Mediana Edad; Cultivo Primario de Células; Ligando RANK/antagonistas & inhibidores; Proteínas Recombinantes/metabolismo

Palabras clave

Anti-receptor activator of nuclear factor kappa B ligand antibody; Degeneration; Intervertebral disc; Matrix-degrading enzyme; Osteoprotegerin; Proinflammatory cytokine; Receptor activator of nuclear factor kappa B; Receptor activator of nuclear factor kappa B ligand

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ligando RANK / Receptor Activador del Factor Nuclear kappa-B / Osteoprotegerina / Degeneración del Disco Intervertebral / Disco Intervertebral Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Musculoskelet Disord Asunto de la revista: FISIOLOGIA / ORTOPEDIA Año: 2019 Tipo del documento: Article País de afiliación: Japón

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