Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.
Neurobiol Learn Mem
; 162: 47-58, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-31103466
ABSTRACT
For social mammals, recognition of conspecifics and discrimination of each other (social memory) is crucial to living in a stable colony. Here, we investigated whether kallikrein-related peptidase 8 (KLK8)-neuregulin 1 (NRG1)-ErbB signaling is crucial for social discrimination behavior using the social discrimination three chamber behavioral test. Klk8 knockout mice (NRG1-deactivated mice) exhibited normal social approach but impaired social discrimination. Intraventricular injection of recombinant NRG1177-246 into Klk8 knockout mice reversed this impaired social discrimination. This study reveals that KLK8 is a key regulator of NRG1-ErbB signaling, which contributes to social discrimination behavior.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Conducta Social
/
Conducta Animal
/
Calicreínas
/
Discriminación Social
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Neurobiol Learn Mem
Asunto de la revista:
BIOLOGIA
/
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Año:
2019
Tipo del documento:
Article