Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.

Eddings, Chelsy R; Arbez, Nicolas; Akimov, Sergey; Geva, Michal; Hayden, Michael R; Ross, Christopher A

Eddings, Chelsy R; Arbez, Nicolas; Akimov, Sergey; Geva, Michal; Hayden, Michael R; Ross, Christopher A.

Afiliación

Eddings CR; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America.
Arbez N; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America.
Akimov S; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America.
Geva M; Prilenia Therapeutics Development LTD, Herzliya, Israel.
Hayden MR; Prilenia Therapeutics Development LTD, Herzliya, Israel; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Ross CA; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America; Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America. Electro

Neurobiol Dis ; 129: 118-129, 2019 09.

Article en En | MEDLINE | ID: mdl-31108174

Asunto(s)

Proteína Huntingtina/metabolismo; Neuronas/efectos de los fármacos; Fármacos Neuroprotectores/farmacología; Piperidinas/farmacología; Receptores sigma/metabolismo; Animales; Células Cultivadas; Humanos; Proteína Huntingtina/genética; Enfermedad de Huntington/metabolismo; Ratones; Ratones Noqueados; Neuronas/metabolismo; Neuronas/patología; Receptor Sigma-1

Palabras clave

3PPP; Huntingtin toxicity; Huntington's disease; Mutant-huntingtin; Neuroprotection; Patient-derived induced pluripotent stem cells; Pridopidine; Primary neurons; Sigma-1 receptor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Receptores sigma / Fármacos Neuroprotectores / Proteína Huntingtina / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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