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Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
Sliepen, Kwinten; Han, Byung Woo; Bontjer, Ilja; Mooij, Petra; Garces, Fernando; Behrens, Anna-Janina; Rantalainen, Kimmo; Kumar, Sonu; Sarkar, Anita; Brouwer, Philip J M; Hua, Yuanzi; Tolazzi, Monica; Schermer, Edith; Torres, Jonathan L; Ozorowski, Gabriel; van der Woude, Patricia; de la Peña, Alba Torrents; van Breemen, Mariëlle J; Camacho-Sánchez, Juan Miguel; Burger, Judith A; Medina-Ramírez, Max; González, Nuria; Alcami, Jose; LaBranche, Celia; Scarlatti, Gabriella; van Gils, Marit J; Crispin, Max; Montefiori, David C; Ward, Andrew B; Koopman, Gerrit; Moore, John P; Shattock, Robin J; Bogers, Willy M; Wilson, Ian A; Sanders, Rogier W.
Afiliación
  • Sliepen K; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Han BW; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA. bwhan@snu.ac.kr.
  • Bontjer I; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Korea. bwhan@snu.ac.kr.
  • Mooij P; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Garces F; Department of Virology, Biomedical Primate Research Centre, 2280 GH, Rijswijk, The Netherlands.
  • Behrens AJ; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Rantalainen K; Department of Therapeutics Discovery, Amgen Research, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
  • Kumar S; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
  • Sarkar A; New England Biolabs Inc., 240 County Road, Ipswich, MA, 01938, USA.
  • Brouwer PJM; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Hua Y; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Tolazzi M; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Schermer E; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Torres JL; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Ozorowski G; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.
  • van der Woude P; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • de la Peña AT; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • van Breemen MJ; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Camacho-Sánchez JM; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Burger JA; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Medina-Ramírez M; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • González N; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Alcami J; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • LaBranche C; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Scarlatti G; AIDS Immunopathology Unit, Instituto de Salud Carlos III, Madrid, 28220, Spain.
  • van Gils MJ; AIDS Immunopathology Unit, Instituto de Salud Carlos III, Madrid, 28220, Spain.
  • Crispin M; Department of Surgery, Duke University Medical Center, Durham, NC, 27710, USA.
  • Montefiori DC; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.
  • Ward AB; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.
  • Koopman G; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
  • Moore JP; Centre for Biological Sciences and Institute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, UK.
  • Shattock RJ; Department of Surgery, Duke University Medical Center, Durham, NC, 27710, USA.
  • Bogers WM; Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Wilson IA; Department of Virology, Biomedical Primate Research Centre, 2280 GH, Rijswijk, The Netherlands.
  • Sanders RW; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, 10021, USA.
Nat Commun ; 10(1): 2355, 2019 05 29.
Article en En | MEDLINE | ID: mdl-31142746
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Anti-VIH / VIH-1 / Vacunas contra el SIDA / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Anticuerpos Neutralizantes / Epítopos Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Anti-VIH / VIH-1 / Vacunas contra el SIDA / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Anticuerpos Neutralizantes / Epítopos Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos