2-(Bipiperidin-1-yl)-5-(nitroaryl)-1,3,4-thiadiazoles: Synthesis, evaluation of in vitro leishmanicidal activity, and mechanism of action.

Mojallal-Tabatabaei, Zahra; Foroumadi, Parham; Toolabi, Mahsa; Goli, Fereshteh; Moghimi, Setareh; Kaboudanian-Ardestani, Sussan; Foroumadi, Alireza

Mojallal-Tabatabaei, Zahra; Foroumadi, Parham; Toolabi, Mahsa; Goli, Fereshteh; Moghimi, Setareh; Kaboudanian-Ardestani, Sussan; Foroumadi, Alireza.

Afiliación

Mojallal-Tabatabaei Z; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Foroumadi P; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Toolabi M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Goli F; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Moghimi S; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Kaboudanian-Ardestani S; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: ardestany@ut.ac.ir.
Foroumadi A; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: aforoumadi@tums.ac.ir.

Bioorg Med Chem ; 27(16): 3682-3691, 2019 08 15.

Article en En | MEDLINE | ID: mdl-31300318

Asunto(s)

Antiprotozoarios/síntesis química; Antiprotozoarios/uso terapéutico; Leishmania major/efectos de los fármacos; Tiadiazoles/síntesis química; Tiadiazoles/uso terapéutico; Antiprotozoarios/farmacología; Estructura Molecular; Relación Estructura-Actividad; Tiadiazoles/farmacología

Palabras clave

1,3,4-Thiadiazole; Anti-leishmanial activity; Leishmania major; Redox system

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiadiazoles / Leishmania major / Antiprotozoarios Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Irán

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