Your browser doesn't support javascript.
loading
Trends in sodium valproate prescriptions among children aged 0 to 14 years between 2010 and 2016: A study based on the French National Health Insurance Database.
Polard, Elisabeth; Degremont, Adeline; Rault, Caroline; Le Nautout, Béranger; Oger, Emmanuel; Biraben, Arnaud; Nowak, Emmanuel.
Afiliación
  • Polard E; Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Department of Clinical Pharmacology, Rennes University Hospital, 35033 Rennes, France; Univ Rennes, EA 7449 REPERES 'Pharmacoepidemiology and Health Services Research', F 35000 Rennes, France.
  • Degremont A; Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Department of Clinical Pharmacology, Rennes University Hospital, 35033 Rennes, France; Univ Rennes, EA 7449 REPERES 'Pharmacoepidemiology and Health Services Research', F 35000 Rennes, France. Electronic address: adeline.degremont@
  • Rault C; Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Department of Clinical Pharmacology, Rennes University Hospital, 35033 Rennes, France.
  • Le Nautout B; Univ Rennes, EA 7449 REPERES 'Pharmacoepidemiology and Health Services Research', F 35000 Rennes, France.
  • Oger E; Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Department of Clinical Pharmacology, Rennes University Hospital, 35033 Rennes, France; Univ Rennes, EA 7449 REPERES 'Pharmacoepidemiology and Health Services Research', F 35000 Rennes, France.
  • Biraben A; Epilepsy Unit, Neurology Department, Rennes University Hospital and INSERM 1099, Signal and Image Processing Laboratory, University of Rennes 1, France.
  • Nowak E; CHU de Brest et Université Européenne de Bretagne, Université de Brest, INSERM CIC 1412, IFR 148, France.
Seizure ; 70: 71-76, 2019 Aug.
Article en En | MEDLINE | ID: mdl-31302303
ABSTRACT

PURPOSE:

After a huge campaign of information on the teratogenic risk of sodium valproate (VPA) having taken place in France we aimed to evaluate the trend of its prescriptions in young epileptic girls.

METHOD:

Using the French National Health Insurance Database we searched for patients aged 0-14 years being supplied an antiepileptic drug (AED) between 2010 and 2016.

RESULTS:

113,362 children received at least one AED, 61,259 boys and 52,103 girls. Compared to 2010-2014 years, VPA was less prescribed in 2016 as first AED (29% vs 37.3% respectively). The difference between the two periods was greater for girls (-41%) than for boys (-12%).

CONCLUSION:

The changing trend of VPA as first AED prescribed, particularly in girls, reflects published evidence in terms of safety.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácido Valproico / Anticonvulsivantes Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Europa Idioma: En Revista: Seizure Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Francia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácido Valproico / Anticonvulsivantes Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Europa Idioma: En Revista: Seizure Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Francia