Your browser doesn't support javascript.
loading
Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.
Wong, Jason Y Y; Zhang, Han; Hsiung, Chao A; Shiraishi, Kouya; Yu, Kai; Matsuo, Keitaro; Wong, Maria Pik; Hong, Yun-Chul; Wang, Jiucun; Seow, Wei Jie; Wang, Zhaoming; Song, Minsun; Kim, Hee Nam; Chang, I-Shou; Chatterjee, Nilanjan; Hu, Wei; Wu, Chen; Mitsudomi, Tetsuya; Zheng, Wei; Kim, Jin Hee; Seow, Adeline; Caporaso, Neil E; Shin, Min-Ho; Chung, Lap Ping; An, She-Juan; Wang, Ping; Yang, Yang; Zheng, Hong; Yatabe, Yasushi; Zhang, Xu-Chao; Kim, Young Tae; Cai, Qiuyin; Yin, Zhihua; Kim, Young-Chul; Bassig, Bryan A; Chang, Jiang; Ho, James Chung Man; Ji, Bu-Tian; Daigo, Yataro; Ito, Hidemi; Momozawa, Yukihide; Ashikawa, Kyota; Kamatani, Yoichiro; Honda, Takayuki; Hosgood, H Dean; Sakamoto, Hiromi; Kunitoh, Hideo; Tsuta, Koji; Watanabe, Shun-Ichi; Kubo, Michiaki.
Afiliación
  • Wong JYY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: jason.wong@nih.gov.
  • Zhang H; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
  • Shiraishi K; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
  • Yu K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Matsuo K; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Wong MP; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
  • Hong YC; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Wang J; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  • Seow WJ; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Wang Z; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Song M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Department of Statistics, Sookmyung Women's University, Seoul, Republic of Korea.
  • Kim HN; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Chang IS; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
  • Chatterjee N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Hu W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Wu C; Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Mitsudomi T; Division of Thoracic Surgery, Kinki University School of Medicine, Sayama, Japan.
  • Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
  • Kim JH; Department of Integrative Bioscience & Biotechnology, Sejong University, Seoul, Republic of Korea.
  • Seow A; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Caporaso NE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Chung LP; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
  • An SJ; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
  • Wang P; Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
  • Yang Y; Shanghai Pulmonary Hospital, Shanghai, China.
  • Zheng H; Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Yatabe Y; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Central Hospital, Nagoya, Japan.
  • Zhang XC; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
  • Kim YT; Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
  • Yin Z; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
  • Kim YC; Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Bassig BA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Chang J; Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Ho JCM; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong.
  • Ji BT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Daigo Y; Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan; Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Ito H; Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Momozawa Y; Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
  • Ashikawa K; Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
  • Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Honda T; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
  • Hosgood HD; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Sakamoto H; Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan.
  • Kunitoh H; Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
  • Tsuta K; Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.
  • Watanabe SI; Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Kubo M; Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Genomics ; 112(2): 1223-1232, 2020 03.
Article en En | MEDLINE | ID: mdl-31306748
ABSTRACT
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article