G37V mutation of Aß42 induces a nontoxic ellipse-like aggregate: An in vitro and in silico study.

Minh Thu, Tran Thi; Huang, Shu-Hsiang; Tu, Ly Anh; Fang, Shang-Ting; Li, Mai Suan; Chen, Yi-Cheng

Minh Thu, Tran Thi; Huang, Shu-Hsiang; Tu, Ly Anh; Fang, Shang-Ting; Li, Mai Suan; Chen, Yi-Cheng.

Afiliación

Minh Thu TT; Institute for Computational Science and Technology, SBI Building, Quang Trung Software City, Tan Chanh Hiep Ward, District 12, Ho Chi Minh City, Viet Nam; Department of Applied Physics, Faculty of Applied Science, Ho Chi Minh City University of Technology - VNU HCM, 268 Ly Thuong Kiet Street, Distri
Huang SH; Department of Medicine, MacKay Medical College, New Taipei City, 252, Taiwan.
Tu LA; Department of Applied Physics, Faculty of Applied Science, Ho Chi Minh City University of Technology - VNU HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Viet Nam.
Fang ST; Department of Medicine, MacKay Medical College, New Taipei City, 252, Taiwan.
Li MS; Institute for Computational Science and Technology, SBI Building, Quang Trung Software City, Tan Chanh Hiep Ward, District 12, Ho Chi Minh City, Viet Nam; Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668, Warsaw, Poland. Electronic address: masli@ifpan.edu.pl.
Chen YC; Department of Medicine, MacKay Medical College, New Taipei City, 252, Taiwan. Electronic address: chen15@mmc.edu.tw.

Neurochem Int ; 129: 104512, 2019 10.

Article en En | MEDLINE | ID: mdl-31374231

Asunto(s)

Sustitución de Aminoácidos; Péptidos beta-Amiloides/genética; Mutación Missense; Fragmentos de Péptidos/genética; Mutación Puntual; Agregado de Proteínas; Secuencias de Aminoácidos; Amiloide/química; Péptidos beta-Amiloides/química; Péptidos beta-Amiloides/toxicidad; Línea Celular Tumoral; Supervivencia Celular; Simulación por Computador; Humanos; Técnicas In Vitro; Modelos Moleculares; Simulación de Dinámica Molecular; Neuroblastoma/patología; Fragmentos de Péptidos/química; Fragmentos de Péptidos/toxicidad; Agregación Patológica de Proteínas/genética; Estructura Secundaria de Proteína

Palabras clave

Aggregation; Alzheimer's disease; Aß; Aß toxicity; G37V mutation; Morphology

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Mutación Puntual / Sustitución de Aminoácidos / Mutación Missense / Agregado de Proteínas Límite: Humans Idioma: En Revista: Neurochem Int Año: 2019 Tipo del documento: Article

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