Regional Gray Matter Volume Links Rest-Activity Rhythm Fragmentation With Past Cognitive Decline.
Am J Geriatr Psychiatry
; 28(2): 248-251, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31377045
ABSTRACT
OBJECTIVES:
We examined the extent to which measures of neurodegeneration and cerebrovascular disease explain the rest-activity rhythm (RAR)-cognition link.METHODS:
Seventy participants (mean age at MRIâ¯=â¯86, standard deviation (SD)â¯=â¯2.6; 53% female) had cognitive, MRI, and accelerometer data. The slope of cognitive decline was defined applying a mixed model to 10 repeated Modified Mini Mental Status Test (3MS) measures over 14 years. Regional gray matter volume (GMV), white matter hyperintensities, and RARs were measured around year 12.RESULTS:
Past 3MS decline was related to RAR fragmentation (per SD ß = -0.43, 95% confidence interval -0.73, -0.14) and lower posterior parietal GMV (per standard deviation ßâ¯=â¯0.47, 95% confidence interval 0.14, 0.79). Higher RAR fragmentation was related to lower posterior parietal GMV (Pearson r = -0.39, nâ¯=â¯70, pâ¯=â¯0.0007), which attenuated the association of RAR fragmentation and past cognitive decline by 17%.CONCLUSIONS:
Longitudinal studies are warranted to understand the temporal relations and mechanisms linking RAR fragmentation and neurodegeneration.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cognición
/
Disfunción Cognitiva
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Sustancia Gris
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Aged80
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Geriatr Psychiatry
Asunto de la revista:
GERIATRIA
/
PSIQUIATRIA
Año:
2020
Tipo del documento:
Article