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Re-elevation of serum amlodipine level after lipid emulsion therapy in an overdose case.
Ando, Motozumi; Nakasako, Shinji; Ariyoshi, Koichi; Yamaguchi, Marie; Sakizono, Kenji; Minowa, Kazushi; Fukushima, Shoji; Sugioka, Nobuyuki; Hashida, Tohru.
Afiliación
  • Ando M; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.
  • Nakasako S; Department of Pharmacy, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Ariyoshi K; Department of Emergency Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Yamaguchi M; Department of Clinical Laboratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Sakizono K; Department of Clinical Laboratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Minowa K; Department of Clinical Laboratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Fukushima S; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.
  • Sugioka N; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.
  • Hashida T; Department of Pharmacy, Kobe City Medical Center General Hospital, Kobe, Japan.
J Clin Pharm Ther ; 44(6): 970-973, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31436900
ABSTRACT
WHAT IS KNOWN AND

OBJECTIVE:

Amlodipine overdose is common; however, the dose and timing of intravenous lipid emulsion (ILE) therapy as a management strategy remain debatable. CASE DESCRIPTION A 73-year-old man received a single bolus (1.5 mL/kg) of ILE therapy following massive ingestion of multiple drugs, including amlodipine. After approximately 20 hours of ILE therapy, the serum amlodipine level that had decreased from 90.2 to 49.9 ng/mL increased to 70.8 ng/mL. WHAT IS NEW AND

CONCLUSION:

A single bolus (1.5 mL/kg) of ILE therapy is probably insufficient to completely capture and partition serum amlodipine following amlodipine overdose.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Amlodipino / Emulsiones Grasas Intravenosas / Sobredosis de Droga / Lípidos Límite: Aged / Humans / Male Idioma: En Revista: J Clin Pharm Ther Asunto de la revista: FARMACIA / TERAPEUTICA Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Amlodipino / Emulsiones Grasas Intravenosas / Sobredosis de Droga / Lípidos Límite: Aged / Humans / Male Idioma: En Revista: J Clin Pharm Ther Asunto de la revista: FARMACIA / TERAPEUTICA Año: 2019 Tipo del documento: Article País de afiliación: Japón