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Physical and Functional Compartmentalization of Archaeal Chromosomes.
Takemata, Naomichi; Samson, Rachel Y; Bell, Stephen D.
Afiliación
  • Takemata N; Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, IN, USA; Biology Department, Indiana University, Bloomington, IN, USA.
  • Samson RY; Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, IN, USA.
  • Bell SD; Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, IN, USA; Biology Department, Indiana University, Bloomington, IN, USA. Electronic address: stedbell@indiana.edu.
Cell ; 179(1): 165-179.e18, 2019 09 19.
Article en En | MEDLINE | ID: mdl-31539494
The three-dimensional organization of chromosomes can have a profound impact on their replication and expression. The chromosomes of higher eukaryotes possess discrete compartments that are characterized by differing transcriptional activities. Contrastingly, most bacterial chromosomes have simpler organization with local domains, the boundaries of which are influenced by gene expression. Numerous studies have revealed that the higher-order architectures of bacterial and eukaryotic chromosomes are dependent on the actions of structural maintenance of chromosomes (SMC) superfamily protein complexes, in particular, the near-universal condensin complex. Intriguingly, however, many archaea, including members of the genus Sulfolobus do not encode canonical condensin. We describe chromosome conformation capture experiments on Sulfolobus species. These reveal the presence of distinct domains along Sulfolobus chromosomes that undergo discrete and specific higher-order interactions, thus defining two compartment types. We observe causal linkages between compartment identity, gene expression, and binding of a hitherto uncharacterized SMC superfamily protein that we term "coalescin."
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Sulfolobus / Proteínas de Ciclo Celular / Cromosomas de Archaea Idioma: En Revista: Cell Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Sulfolobus / Proteínas de Ciclo Celular / Cromosomas de Archaea Idioma: En Revista: Cell Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos