The Maori and Pacific specific CREBRF variant and adult height.
Int J Obes (Lond)
; 44(3): 748-752, 2020 03.
Article
en En
| MEDLINE
| ID: mdl-31543511
ABSTRACT
BACKGROUND:
The CREBRF missense variant (p.Arg457Gln) is paradoxically associated with lower risk of type 2 diabetes, yet higher body mass index (BMI). Here we sought to determine whether this CREBRF variant might be associated with adult height.METHODS:
Linear regression was used to analyse the association of the CREBRF minor (A) allele with height in 2286 Maori and Pacific adults living in Aotearoa/New Zealand. A potential type 2 diabetes index event was corrected to account for a bias that may be the cause of paradoxical association between the CREBRF diabetes-protective allele and higher BMI and height.RESULTS:
The CREBRF protective allele was associated with increased adult height (ß = 1.25 cm, P = 3.9 × 10-6), with the effect being more pronounced in males. The lower odds of diabetes remained similar when analyses were adjusted for height (OR = 0.67-0.65). We found no evidence of a diabetes index event bias to explain the paradoxical effect of CREBRF with either BMI or height and diabetes. The orthologous CREBRF p.Arg457Gln variant was created in knock-in mice to independently assess the effect of the variant, and length was found to be greater in male mice at 8 weeks of age.CONCLUSION:
These data taken together indicate that CREBRF p.Arg457Gln is associated with taller stature in Maori and Pacific adults.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estatura
/
Proteínas Supresoras de Tumor
/
Nativos de Hawái y Otras Islas del Pacífico
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Animals
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Female
/
Humans
/
Male
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Int J Obes (Lond)
Asunto de la revista:
METABOLISMO
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia