Therapeutic Potential of the miRNA-ATM Axis in the Management of Tumor Radioresistance.

Rezaeian, Abdol-Hossein; Khanbabaei, Hashem; Calin, George A

Rezaeian, Abdol-Hossein; Khanbabaei, Hashem; Calin, George A.

Afiliación

Rezaeian AH; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. gcalin@mdanderson.org rezaeiana@gmail.com.
Khanbabaei H; Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Calin GA; Departments of Experimental Therapeutics and Leukemia and the Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas. gcalin@mdanderson.org rezaeiana@gmail.com.

Cancer Res ; 80(2): 139-150, 2020 01 15.

Article en En | MEDLINE | ID: mdl-31767626

ABSTRACT

ABSTRACT

The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response (DDR) upon DNA double-strand breaks. ATM orchestrates the DDR by modulating the expression of various miRNAs through several mechanisms. On the other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3'-untranslated region of ATM mRNA. This review addresses the therapeutic application and molecular mechanisms that underlie the intricate interactions between miRNAs and ATM. It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor microenvironments.

Asunto(s)

Antineoplásicos/farmacología; Proteínas de la Ataxia Telangiectasia Mutada/genética; Quimioradioterapia/métodos; MicroARNs/metabolismo; Neoplasias/terapia; Tolerancia a Radiación/genética; Regiones no Traducidas 3'/genética; Antagomirs/farmacología; Antagomirs/uso terapéutico; Antineoplásicos/uso terapéutico; Hipoxia de la Célula/genética; Hipoxia de la Célula/efectos de la radiación; Terapia Combinada/métodos; Roturas del ADN de Doble Cadena/efectos de la radiación; Reparación del ADN/efectos de los fármacos; Reparación del ADN/efectos de la radiación; Regulación Neoplásica de la Expresión Génica; Humanos; MicroARNs/agonistas; MicroARNs/antagonistas & inhibidores; MicroARNs/genética; Neoplasias/genética; Tolerancia a Radiación/efectos de los fármacos; Transducción de Señal/genética; Transducción de Señal/efectos de la radiación; Microambiente Tumoral/genética; Microambiente Tumoral/efectos de la radiación

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tolerancia a Radiación / MicroARNs / Quimioradioterapia / Proteínas de la Ataxia Telangiectasia Mutada / Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: Cancer Res Año: 2020 Tipo del documento: Article

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