Effect of plasma osmolality and intraocular pressure on fluid movement across the blood-retinal barrier.
Invest Ophthalmol Vis Sci
; 29(11): 1747-9, 1988 Nov.
Article
en En
| MEDLINE
| ID: mdl-3182207
ABSTRACT
The inward permeability of the blood-retinal barrier to carboxyfluorescein was determined in monkey eyes with and without rhegmatogenous retinal detachment (RD). In the absence of changes in the diffusional permeability of the retinal pigment epithelium (RPE), inward permeability changes reflect changes in fluid flow across the RPE. Intravenous injection of mannitol resulted in a 15 mosmol/kg increase in plasma osmolality which decreased inward permeability 37% in eyes with RD and 21% in eyes with vitrectomy alone. When the intraocular pressure was raised 20 mm Hg above normal, inward permeability decreased 29% in eyes with RD and 32% in normal eyes. It is concluded that fluid flow across the blood-retinal barrier is influenced by both plasma osmolality and intraocular pressure.
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Banco de datos:
MEDLINE
Asunto principal:
Epitelio Pigmentado Ocular
/
Sangre
/
Líquidos Corporales
/
Desprendimiento de Retina
/
Barrera Hematorretinal
/
Presión Intraocular
Límite:
Animals
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Año:
1988
Tipo del documento:
Article