Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines.

Krammer, Florian; Weir, Jerry P; Engelhardt, Othmar; Katz, Jacqueline M; Cox, Rebecca Jane

Krammer, Florian; Weir, Jerry P; Engelhardt, Othmar; Katz, Jacqueline M; Cox, Rebecca Jane.

Afiliación

Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Weir JP; Division of Viral Products, Food and Drug Administration, Bethesda, MD, USA.
Engelhardt O; Division of Virology, National Institute for Biological Standards and Control, Potters Bar, UK.
Katz JM; Formerly Influenza Branch, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Cox RJ; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.

Influenza Other Respir Viruses ; 14(2): 237-243, 2020 03.

Article en En | MEDLINE | ID: mdl-31837101

ABSTRACT

ABSTRACT

BACKGROUND:

This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, Italy, from March 31, 2019, to April 2, 2019.

CONCLUSIONS:

Furthermore, we review current correlates of protection against influenza virus infection and disease and their usefulness for the development of next generation broadly protective and universal influenza virus vaccines.

Asunto(s)

Vacunas contra la Influenza/inmunología; Gripe Humana/inmunología; Animales; Anticuerpos Neutralizantes/sangre; Anticuerpos Antivirales/sangre; Linfocitos T CD4-Positivos/inmunología; Linfocitos T CD8-positivos/inmunología; Pruebas de Inhibición de Hemaglutinación; Glicoproteínas Hemaglutininas del Virus de la Influenza/inmunología; Humanos; Inmunidad Mucosa; Subtipo H1N1 del Virus de la Influenza A/inmunología; Vacunas contra la Influenza/biosíntesis; Gripe Humana/prevención & control; Modelos Animales; Neuraminidasa/sangre; Neuraminidasa/inmunología; Infecciones por Orthomyxoviridae/inmunología; Infecciones por Orthomyxoviridae/prevención & control; Pruebas Serológicas/métodos; Vacunación

Palabras clave

CD4; CD8; HI; MN; NI; correlates of protection; influenza; influenza vaccine; mucosal immunity; stalk antibodies

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Gripe Humana Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Influenza Other Respir Viruses Asunto de la revista: VIROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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