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Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Hart, Peter C; Kenny, Hilary A; Grassl, Niklas; Watters, Karen M; Litchfield, Lacey M; Coscia, Fabian; Blazenovic, Ivana; Ploetzky, Lisa; Fiehn, Oliver; Mann, Matthias; Lengyel, Ernst; Romero, Iris L.
Afiliación
  • Hart PC; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
  • Kenny HA; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
  • Grassl N; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  • Watters KM; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
  • Litchfield LM; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA.
  • Coscia F; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  • Blazenovic I; West Coast Metabolomics Center, University of California, Davis Genome Center, Davis, CA, USA.
  • Ploetzky L; West Coast Metabolomics Center, University of California, Davis Genome Center, Davis, CA, USA.
  • Fiehn O; West Coast Metabolomics Center, University of California, Davis Genome Center, Davis, CA, USA.
  • Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  • Lengyel E; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: elengyel@uchicago.edu.
  • Romero IL; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: iromero@bsd.uchicago.edu.
Cell Rep ; 29(12): 4086-4098.e6, 2019 12 17.
Article en En | MEDLINE | ID: mdl-31851935
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Células del Estroma / Subunidad alfa del Factor 1 Inducible por Hipoxia / Microambiente Tumoral / Carcinogénesis / Metformina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Células del Estroma / Subunidad alfa del Factor 1 Inducible por Hipoxia / Microambiente Tumoral / Carcinogénesis / Metformina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos