Specificity Assessment of CRISPR Genome Editing of Oncogenic EGFR Point Mutation with Single-Base Differences.

Bae, Taegeun; Kim, Hanseop; Kim, Jeong Hee; Kim, Yong Jun; Lee, Seung Hwan; Ham, Byung-Joo; Hur, Junho K

Bae, Taegeun; Kim, Hanseop; Kim, Jeong Hee; Kim, Yong Jun; Lee, Seung Hwan; Ham, Byung-Joo; Hur, Junho K.

Afiliación

Bae T; Department of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Kim H; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea.
Kim JH; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Kim YJ; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Lee SH; Department of Pathology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Ham BJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea.
Hur JK; Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Korea.

Molecules ; 25(1)2019 Dec 22.

Article en En | MEDLINE | ID: mdl-31877894

Asunto(s)

Edición Génica/métodos; Mutación Puntual; Sistemas CRISPR-Cas; ADN Complementario/genética; ADN Intergénico/genética; Receptores ErbB/genética; Humanos

Palabras clave

CRISPR; PAM; off-target; single-base precision; specificity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Mutación Puntual / Edición Génica Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article

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